Njengamanye amagciwane amanengi, i-HIV yaqala ezilwaneni futhi yadluliselwa ebantwini. Endabeni ye-HIV, igcikwane lasuka kuboChimpanzee  lasezinkawini ze-sooty mangabey laya ebantwini. 

IChimpanzee lezinkawu zeSooty Mangabey lazo ziba legcikwane elifana leHIV elithiwa lona SIV. Kulolunye hlobo lwegcikwane leli elithiwa SIVcpv eliphosa kufanana leHIV. 

Ukwazi lokhu, kutsho ukuthi singatsho ukuthi i-HIV phose yavela ezinkawini  lasezimfeni ezile-SIVcpv. Utshintsho oluncane ku-DNA ye-SIV lwatsho ukuthi leli gcikwane lakwazi ukudluliselwa lisuka kuboChimpanzee lasezinkawini lisiya ebantwini. 

Kungenzeka ukuthi abantu bokuqala babamba leli gcikwane ngokudla izinkawu lamaChimpanzee okwakule-SIV loba ngokufaka igazi labo emanxebeni abawathola lapho bezingela. Zinengi izinganekwane mayelana lemvelaphi yegcikwane  lengculaza, abantu bathi igcikwane lengculaza ladalwa emalebhu ngabososayenzi noma kwakuyisijeziso esivela kuNkulunkulu - lezi zinganekwane azilona iqiniso.

Igciwane luhlobo ‘lwegcikwane’, into engakwenza ugule. Mancane kakhulu, awukwazi ukuwabona ngaphandle kosizo lwesibonakhulu esilamandla kakhulu. Amagciwane awakwazi ukuphila ngokwawo.   

Adinga ‘indawo yokuhlala’ ukuze aphile futhi aphindaphinde. Esimeni se-HIV, igcikwane lingaphila kuphela ngaphakathi emzimbeni womuntu. Kuzo zonke izimo, amagciwane asebenza ngokuhlasela enye ‘into ephilayo’ (lokhu kuhlanganisa izilimo, izinyamazana kanye labantu - nomaiyiphi into ephilayo). Adinga indawo yokuhlala   

Nxa sengene emzimbeni angena kuCell elithile. Nxa sengaphakathi asebenzisa imishini yeseli ukuze enze amakhophi. Amanye amagcikwane okungenzeka ukuthi uke wezwa ngawo yilawa: i-SARS-CoV-2 - igcikwane elidala i-COVID-19, amagcikwane omkhuhlane, igcikwane le-herpes noma igcikwane elidala isifo senyawo lomlomo ezinkomeni.