Bengakakufaki  kuPEP abezempilakahle  badinga ukuzwisisa ubungozi obuvezwe kuwe. Badinga ukuqiniseka ukuthi kulobungozi ngempela bokudluliselwa kwegciwane leHIV. Kulezindlela ezithile kuphela ezingadluliselwa ngazo i-HIV, ngakho nxa lezi zingasebenzi kuwe, ngeke udinge ukuthatha i-PEP. 

Bazobuza ukuthi luhlobo luphi lwesenzakalo olwenzakeleyo. Nxa uke waya emacansini ungazivikelanga, bangafuna ukwazi ukuthi luhlobo luphi (vaginal, anal noma ngomlomo) lokuthi uyasazi yini isimo se-HIV somunye wakho. Imibuzo yabo ayenzelwa ukukwenza uzizwe ulamahloni futhi akufanele uzizwe sengathi umuntu uyakwahlulela, bazama nje ukuthola ukunakekelwa kwempilo okufanele.

Yebo, kuyakhuthazwa  ukuthi uqhubeke usebenzisa amakhondomu ngesikhathi uthatha i-PEP. Lokhu kungenxa yokuthi i-PEP kungenzeka ingasebenzi futhi nxa ulokhe uqhubeka usiba sengozini ye-HIV  ngesikhathi uthatha ukwelatshwa. Noma uthatha i-PEP, kusekhona ithuba lokuthi kungenzeka lingasebenzi nge-100%. Ukusebenzisa amakhondomu ngesikhathi uthatha i-PEP kutsho ukuthi umisa ukudlulisa i-HIV kubangane bakho. 

I-PEP futhi ayivimbi ukukhulelwa noma amanye ama-STI, ngakho-ke kungumqondo omuhle ukuqhubeka usebenzisa amakhondomu.

noma kungela umngcele kukhangelwe izikhathi ongathatha ngazo Ipep, yona ayidalelwanga ukuthi umuntu ahlale eyisebenzisa mtshokotsho. Nxa uzithola kufanele uthathe iPEP njalonjalo kudingeka ukhulume labezempilakahle ukuze bakuncedise ngezinye indlela zokuvikela iHIV ongazisebenzisa. IPREP ingakuvikela ekutholeni iHIV njalo ingakuvikela ngcono kule PEP.